The network centre is hosted by the University of Heidelberg and coordinated by Philipp Zanger at the Institute of Public Health, Unit of Epidemiology and Biostatistics,
and Dennis Nurjadi at the Department of Infectious Diseases, Medical Microbiology and Hygiene.
It was initiated in 2012 in response to findings on the import of Panton-Valentine Leukocidin-positive Staphylococcus aureus through nasal carriage and skin infections in travellers returning from the tropics and subtropics published in Clinical Infectious Diseases.
The second focus of research under scrutiny in collaboration with the working group of Klaus Heeg at the Department of Infectious Diseases in Heidelberg are host determinants of S. aureus colonization and infection. Using cell culture models and in vitro assays, we identify immune mechanisms of potential importance for S. aureus defence and then study their impact on colonization and infection in human populations. Through this novel data on the immunoepidemiology of S. aureus, we aim to provide key knowledge for the development of infection control interventions, including vaccines.
Some of the immunoepidemiological and genomic data that emerge from our projects have a complex structure. We collaborate with Sabine Gabrysch at the Unit for Epidemiology and Biostatistics whenever refined modelling techniques are needed for data analysis.
Nurjadi D, Kain M, Marcinek P, Gaile M, Heeg K, Zanger P (2016)
Ratio of T-Helper Type 1 (Th1) to Th17 Cytokines in Whole Blood Is Associated With Human β-Defensin 3 Expression in Skin and Persistent Staphylococcus aureus Nasal Carriage.
Journal of Infectious Diseases 214:1744-1751.
Nurjadi D, Herrmann E, Hinderberger I, Zanger P (2013)
Impaired β-defensinexpression in human skin links DEFB1 promoter polymorphisms with persistent Staphylococcus aureus nasal carriage.
Journal of Infectious Diseases 207:666-74. doi: 10.1093/infdis/jis735.
Zanger P, Nurjadi D, Gaile M, Gabrysch S, Kremsner PG (2012)
Hormonal contraceptive use and persistent Staphylococcus aureus nasal carriage.
Clinical Infectious Diseases 55:1625-32. doi: 10.1093/cid/cis778.
Nurjadi D, Lependu J, Kremsner PG, Zanger P (2012)
Staphylococcus aureus throat carriage is associated with ABO-/secretor status.
Journal of Infection 65:310-7. doi: 10.1016/j.jinf.2012.05.011.
Zanger P, Nurjadi D, Vath B, Kremsner PG (2011)
Persistent nasal carriage of Staphylococcus aureus is associated with deficient induction of human beta-defensin 3 after sterile wounding of healthy skin in vivo.
Infection and Immunity 79:2658-62. doi: 10.1128/IAI.00101-11.
Zanger P, Holzer J, Schleucher R, Scherbaum H, Schittek B, Gabrysch S (2010)
Severity of Staphylococcus aureus infection of the skin is associated with inducibility of human beta-defensin 3 but not human beta-defensin 2.
Infection and Immunity 78:3112-7. doi: 10.1128/IAI.00078-10.
Zanger P, Holzer J, Schleucher R, Steffen H, Schittek B, Gabrysch S (2009)
Constitutive expression of the antimicrobial peptide RNase 7 is associated with Staphylococcus aureus infection of the skin.
Journal of Infectious Diseases 200:1907-15. doi: 10.1086/648408.